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A ‘Game Changer’ For Organ Transplants: Blood Type of Donor Kidneys Altered in Breakthrough Research_我的网站
A | Breakthrough new research could significantly increase supply of organs for people with rarer blood types waiting for a transplant, reported The Guardian.,A team of scientists from the University of Cambridge have successfully altered the blood type of three donor kidneys. By flushing blood infused with a special enzyme through a human kidney the scientists removed the blood type markers lining the blood vessels of the organ.,The procedure required using a device that is connected with a donor’s kidney to pass oxygenated blood through it - a normothermic perfusion machine. As a result, the organ was converted to type O, considered the universal donor.,Blood Group Compatible,As the blood type of a donor must be compatible with the recipient’s, the new development could increase the supply of kidneys available for transplant.,A kidney from someone with blood type A cannot be transplanted to someone with blood type B, or visa versa. In such a case, the receiving body’s immune system would reject the new organ, interpreting the different blood type as foreign.,So changing the blood type to the universal O would mean the donor organ could be used for people with any blood type.,“Our confidence was really boosted after we applied the enzyme to a piece of human kidney tissue and saw very quickly that the antigens were removed. After this, we knew that the process is feasible, and we just had to scale up the project to apply the enzyme to full-size human kidneys,” Serena MacMillan, a PhD student at the University of Cambridge, said.,Scientists involved in the research, funded by charity Kidney Research UK and due to be published in the British Journal of Surgery, clarified that the outcome might have particular implications for minority ethnic groups.,Science & TechGood News for ABs: Scientists Can Now Change People's Blood Type21 February, 16:34 GMT,Some blood groups such as O Rh positive and B Rh positive are more prevalent among black, Asian and minority ethnic communities. To complicate matters further, some rare blood types are only found within the black, Asian and minority ethnic communities,This typically places them at a disadvantage, as they struggle to find a match. With low donation rates from these populations, stressed the researchers, sometimes such patients wait for as long as over a year for a compatible donor. They cited figures from 2020-21 showing that just over 9% of total organ donations in the UK came from black and minority ethnic donors. On the other hand, black and minority ethnic patients make up 33% of the kidney transplant waiting list.,“It’s very exciting to think about how this could potentially impact so many lives,” added Serena MacMillan.,The “potentially gamechanging” research was applauded by Dr Aisling McMahon, the executive director of research at Kidney Research UK.,The scientists will now test the reintroduction of other blood types and observe how the novel approach in clinical settings.。 12月4日，记者从省自然资源厅了解到，目前，我省沈阳、大连两个市级国土空间总体规划已获国务院批复，其他12个市和41个县（市）国土空间总体规划全部通过省政府审批。我省成为继四川之后，全国第二个完成省市县三级国土空间总体规划批复的省份。 自4月1日《辽宁省国土空间规划（2021—2035年）》获国务院批准后，省自然资源厅为做好市县国土空间总体规划编制审查工作、提高规划审批效率和质量，创新开展市县级国土空间总体规划技术审查，全面规范细化审查工作的内容、方式、技术标准、保障制度，不断优化审查程序、加快审查进度、严把审查标准。历时7个多月，形成时间质量“双控双优”的国土空间规划审批工作模式。 省自然资源厅相关负责人介绍，在市县国土空间总体规划推进批复实施过程中，我省根据国土空间规划内容的相关性和初步明确的80个审查要点，按类别建立7个审查模块，逐一明确细化各模块的重点审查内容。为加快审查进度、提高成果质量，我省规范审查方式及流程，采取联审联查“五步走”的方式，对12个地市和41个县（市）共计53个审查单元的文本、图集、附表等规划成果进行综合技术审查，形成一体联动、环环相扣、无缝衔接的工作闭环。 在审查效率及质量提升方面，我省立足自身，以各市县级国土空间规划现有成果为基础，对照“规划好用、管用、实用”标准，制定市县级规划审查的“辽宁标准”，确保规划成果完整、统一、规范。
B | 同时，基于规划“一张图”系统，我省按照“统一数据库标准、统一汇交要求、统一质检要求”，在规划审查的同时，有序开展市县级国土空间总体规划成果的汇交和数据库质检工作。 下一步，省自然资源厅将进一步完善“四级三类”国土空间规划体系，巩固和提升“多规合一”改革成果，全面提升辽宁空间治理体系和治理能力现代化水平。 责任编辑：李丹。
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